Open Letter on the Electromagnetic Hyper-Sensitivity Research

Open Letter is available in pdf format from this link:

Open Letter on the EHS research (dated)

February 4, 2018

To the attention of:

  • The World Health Organization: Director-General Tedros Adhanom Ghebreyesus; info@who.int; @DrTedros; @DrTedros.Official
  • The WHO EMF Project: Head Emilie T. van Deventer vandeventere@who.int
  • The International Commission on Non-Ionizing Radiation Protection (ICNIRP):Chair Eric van Röngen; vanrongen@icnirp.org
  • The European Commission Directorate for Research and Innovation:Commissioner Carlos Moedas; cab-moedas-contact@ec.europa.eu
  • The Australian Radiation Protection and Nuclear Safety Agency (ARPANSA): CEO Lars-Magnus Larsson; info@arpansa.gov.au
  • The National Health and Medical Council (NHMRC): CEO Anne Kelso; nhmrc@nhmrc.gov.au

*****

The end of the road for EHS (IEI-EMF) provocation studies

Dariusz Leszczynski, PhD, DSc

Adjunct Professor of Biochemistry, University of Helsinki, Finland

Chief Editor of ‘Radiation and Health’ specialty, Frontiers in Public Health, Lausanne, Switzerland

*****

Research funding and reviewing agencies should re-consider their stance on the importance of the research on EHS/IEI-EMF. Research should continue but the approach should change. The dominant study protocol till now, provocation studies, need to be replaced with studies examining molecular level physiology changes. Continuation of the research using provocation studies will not provide reliable scientific answers concerning EHS/IEI-EMF. Continuation of research using provocation studies approach is simply a waste of time and scarce resources.

*****

Part of the population considers themselves as sensitive to radiation emitted by the wireless communication devices and networks. Different studies have indicated that ca. 0.5 – 11% of the population might be experiencing sensitivity symptoms. This ailment, called either electromagnetic hyper-sensitivity (EHS) or idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF), is currently not considered by the World Health Organization as being caused by the exposures to electromagnetic fields (EMF). While the symptoms experienced by some persons are acknowledged as health impairment, the cause of these symptoms is considered to be unknown.

Numerous experimental provocation studies (over 70) were executed to determine whether EMF exposure causes EHS. In provocation studies, volunteers are exposed to radiation emitted by the wireless communication devices, in controlled conditions, and asked whether they get health symptoms and whether they recognize when the radiation is on/off. Answers provided by the study subjects are subjective and not objective experimental data. Collectively, the provocation studies have indicated a lack of causality between the EHS symptoms and exposures to EMF.

As I argue below, all of the to-date executed EHS provocation studies provide unreliable results because of several drawbacks in the design and execution of the experiments.

Using, as it is done now, of such ‘subjective’ and scientifically unreliable data to support health policy decisions concerning the EHS/IEI-EMF is a mistake.

Any attempts at improving the methodology of the provocation studies will not lead to the generation of ‘objective’ and reliable scientific data. The data will remain to be ‘subjective’ and scientifically unreliable.

Currently, Australia leads the EHS research

A research group at the Wollongong University in Australia, part of the Australian Centre for Electromagnetic Bioeffects Research (ACEBR) funded by the National Health and Medical Research Council (NHMRC), is currently playing a leading role in the research on EHS. The research on EHS, executed by the Wollongong group, follows the suggestions provided by the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA).

In June 2017, ARPANSA published Technical Report 178: Radiofrequency Electromagnetic Energy and Health: Research Needs.

In the Report, specified as ‘special area of research’, was listed research on EHS/IEI-EMF. The authors of the Report consider research on EHS as follows:

  • it is not clear that there is sufficient evidence to justify further research in this area
  • consistency of well conducted provocation studies further research using this approach is not a high priority
  • improving the methodology in provocation studies may justify further research as a low to medium priority

This means that the ARPANSA considers EHS research as of low importance and questions the need for further research altogether. This is a mistake.

The Question: is EHS caused by EMF?

The answer to the question whether EMF might cause EHS is – yes.

There is no scientific reason why the EMF could not cause EHS in some part of the human population. There is a well-known, and scientifically well-established, phenomenon of the individual sensitivity (Foray et al. 2012). Individual sensitivity means that, because of the genetic and the epigenetic differences between people, different persons have different sensitivity to the same exposing factor (radiation or chemicals).

The phenomenon of the individual sensitivity to radiation is well known for ionizing radiation (Bourguignon et al. 2005a, 2005b), for non-ionizing ultraviolet radiation (Rees 2004, Kelly et al. 2000) and for ultrasound (Barnett et al. 1997).

Therefore, it is scientifically justified to suspect (assume) that the individual sensitivity exists also for the EMF exposures. However, the essential, but still unanswered questions are:

  • what are the levels of EMF that are tolerated without any adverse health effects by the majority of the population and,
  • what are the physiological pre-conditions for the higher sensitivity to EMF.

In the ARPANSA Report, the so-called ‘well conducted provocation studies’ have major methodological drawbacks that invalidate their scientific conclusions.

Drawback #1. False claim concerning experimental volunteer group

The scientists executing provocation studies claim to be examining a causality link between EHS and EMF in volunteers suffering from the EHS. However, the scientists do not know how many, if any at all, actual EHS persons are present in the experimental group of the volunteers.

In all provocation studies the experimental group has been assembled from the persons that responded to a recruitment announcement by the scientists. Because there is not existing any objective method to diagnose the EHS, the scientists rely completely on the volunteers’ self-diagnosis.

Correctness of the self-diagnosis is very uncertain because the symptoms of the EHS are very non-specific and similar to symptoms experienced in e.g. allergy or emotional stress. The self-diagnosis, made by the EHS person, might be in error. The self-diagnosed EHS volunteer might assume that the symptoms are caused by the EMF exposure when, in reality, these symptoms might be caused by other, non-EMF factor(s) present in the environment.

This means that the group of the volunteer EHS persons might be contaminated, to an unknown degree, by erroneously self-diagnosed EHS persons. In fact, in extreme case, it might be that none of the EHS volunteers has a correct self-diagnosis of the EHS. Because the volunteer groups in the provocation studies are small, or extremely small, as in the recent study from the Wollongong group (n=3!)(Verrender et al. 2017), the potential impact of the ‘contamination’ by the falsely self-diagnosed EHS will have significant impact on the study outcome.

Drawback #2. Bias introduced by exclusion of persons with prior health problems

In the selection of the volunteers for the EHS provocation studies process, performed by the scientists, persons with the pre-existing health problems are excluded. This might be a bias-introducing factor. The scientists do not know whether any pre-existing health impairment(s) might pre-dispose a person to become the EHS sufferer. Therefore, exclusion of persons based on pre-existing health condition(s) is incorrect at this discovery stage. Persons with pre-existing health problems that claim to be self-diagnosed EHS sufferers should be included in the study but might be analyzed as a separate sub-group.

Drawback #3. Bias introduced by fear and by reputation of the research group

An additional bias might be introduced, seemingly independently of the scientists, when the volunteers who expressed interest in participation in the study, withdraw or are not responding to scientists’ inquiries. E.g. in the case of Verrender and co-workers’ study (Verrender et al. 2017) the number of volunteers who withdrew from the study was very high – 16 persons out of the initially agreed 25. The withdrawals might be caused by fear of the health effects caused by the voluntary radiation exposure in the experiments. However, there might be also a scientists’ reputation-dependent withdrawal. This aspect has not been mentioned or examined in any of the provocation studies. When the initially agreeable volunteers become aware of the publication record of the scientists and their publicly expressed opinions about the EHS, it might cause withdrawal of some of the volunteers, who might ‘distrust the scientists’.

Drawback #4. Unproven methodology of the provocation studies – lack of positive controls

Another problem with the EHS provocation studies is the experimental set-up and methodology. None of the experimental exposure set-ups and methods to analyze volunteers’ responses to exposures have been proven to be sufficient and adequate to detect a causal link between the EMF exposures and EHS. Assuming that the EHS phenomenon exists, as presented above, the scientists have had no positive controls in their experiments to show that their experimental approach works correctly. It is unclear whether the methods, assumed to be adequate for detecting EHS, have indeed had the capability to do so. Furthermore, the design of all provocation studies has been set to detect only an acute EHS, hence being unsuitable to detect delayed or chronic EHS outbreaks.

Drawback #5. Placebo & nocebo effects

It is likely that the conclusions of EHS provocation studies are invalidated by the placebo and nocebo effects. Placebo and nocebo show the ability of the human mind and beliefs to alter the physiology of the human body (Benedetti et al, 2011, Tinnermann et al. 2017). All persons volunteering in the EHS provocation studies certainly have an opinion about the possible effects of EMF on human health, no matter what this opinion is. The responses given by the self-diagnosed EHS, given in the course of the experiments, have certainly been influenced by the volunteers’ pre-existing opinions about the EHS and by the emotional stress caused by the participation in an experiment. Furthermore, the experiment-associated emotional stress will not be eliminated by performing experiments at the home of the volunteer instead of the laboratory.

Thus, data collected in the EHS provocation studies is not reliable and objective but it is unreliable and subjective, because it is based on subjective feelings and beliefs. Claiming that such subjective, beliefs-contaminated, data is scientifically reliable is incorrect.

The above-listed methodological drawbacks clearly indicate that the data obtained in all to-date executed EHS provocation studies is unreliable and insufficient, neither to prove nor to disprove, the existence of causal link between the EHS and EMF.

What next with the EHS research?

The provocation approach needs to be replaced. It is a high time to stop research efforts focused on provocation tests, being of low sensitivity and producing subjective data, and move on to the physiology-based research. Physiological studies, examining the molecular level responses of human tissues and organs to EMF exposures, will provide the evidence of individual sensitivity and basis for further research (Leszczynski 2014).

Research on sensitivity to EMF needs re-focusing

Finally, the discussion about human sensitivity to the EMF has been severely skewed not only by the demands and attitudes of the self-diagnosed EHS persons but also by the attitudes of the scientists who “blindly” followed in their footsteps and conducted, nearly solely, provocation studies, instead of considering other scientific approaches.

The research and the debate should shift from the issue of the validity of the self-diagnosis of the EHS to the more general problem of whether the current EMF exposure limits are sufficiently protective for all users, no matter their age or health status. Are some persons more sensitive to EMF exposures?

Efforts should be focused on finding, through physiological means,  whether different subsets of human population have different sensitivity to the EMF and whether differences in the sensitivity to EMF will translate, in due time, into health risks or whether human bodies will adapt and become resilient. This can be achieved by using modern methods of proteomics, transcriptomics and other ‘omics’ technologies to find proteins, genes and metabolites that are affected by the EMF exposures. This detailed molecular level response information should be then used to formulate the knowledge-based hypotheses concerning possible effects of EMF exposures on human health.

References

  • Barnett SB, Rott HD, ter Haar GR, Ziskin MC, Maeda K. 1997. The sensitivity of biological tissue to ultrasound. Ultrasound Med Biol 23:805-812.
  • Benedetti F, Carlino E, Pollo A. 2011. How Placebos Change the Patient’s Brain. Neuropsychopharmacology 36:339-354.
  • Bourguignon MH, Gisone PA, Perez MR, Michelin S, Dubner D, Di Giorgio M, Carosella ED. 2005a. Genetic and epigenetic features in radiation sensitivity. Part I: Cell signalling in radiation response. Eur J Nucl Med Mol Imaging 32:229-246.
  • Bourguignon MH, Gisone PA, Perez MR, Michelin S, Dubner D, Di Giorgio M, Carosella ED. 2005b. Genetic and epigenetic features in radiation sensitivity. Part II: implications for clinical practice and radiation protection. Eur J Nucl Med Mol Imaging 32:351-368.
  • Foray N, Colin C, Bourguignon M. 2012. 100 Years of Individual Radiosensitivity: How We Have Forgotten the Evidence. Radiology 264:627-631.
  • Kelly DA, Young AR, McGregor JM, Seed PT, Potten CS, Walker SL. Sensitivity to Sunburn Is Associated with Susceptibility to Ultraviolet Radiation–induced Suppression of Cutaneous Cell–mediated Immunity. J Exp Med 191:561-566.
  • Leszczynski D. 2014. The Grand Challenge: Use of a New Approach in Developing Policies in the Area of Radiation and Health. Front Public Health 2:50.
  • Rees JL. 2004. The Genetics of Sun Sensitivity in Humans. Am J Hum Genet 75:739-751.
  • Tinnermann A, Geuter S, Sprenger C, Finsterbusch J, Büchel C. 2017. Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia. Science 358:105-108.
  • Verrender A, Loughran SP, Anderson V, Hillert L, Rubin GJ, Oftedal G, Croft RJ. 2017. IEI-EMF provocation case studies: A novel approach to testing sensitive individuals. Bioelectromagnetics DOI: 10.1002/bem.22095.

 

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4 thoughts on “Open Letter on the Electromagnetic Hyper-Sensitivity Research

  1. Pingback: Lettera aperta all'OMS sulla elettrosensibilità | NoGeoingegneria

  2. From what I frequently read I understand that EHS sufferers might be giving genuine researchers (and industry troll researchers too) feedback that appears as ‘false positives’.
    I strongly suggest that there are individuals out there that will compare Electromagnetic bombardment to being physically injured or assaulted because to them it is so traumatic.

    So what I’m saying is that when any trauma occurs and the victim is later questioned…they might (and I believe will) act somewhat hesitant on the subject…this manifests as a degree of irrationality on the subject of their particular trauma…a sort of avoidance of the whole subject…because some of the trauma persists even if only as a memory now (think about individuals who were’shell shocked’ after a battle or war).

    Individuals very sensitive to EMFs have not only been traumatized… but have had this compounded by daily,or ongoing(24/7), assaults on their wellbeing and health.

    Even if ,as is the case, some of these victims are surgeons and lawyers, do not expect total ‘accuracy’ as to their ability to recognize fields (some will and some won’t).I advocate that this is because ongoing trauma (even when reminded of the subject) can create irrationality when the stimulus is encountered again….as in the experimental situation.

    This irrationality or ‘inaccuracy’ doesn’t mean that there is a nacebo effect really…it means that the trauma of EMF is being ‘re stimulated’ in the test subject by the experiment itself and thus irrationality can definitely occur.Such ‘re stimulation’ can occur just by mentioning the word Wifi!

    Why would people who are not hypochondriacs want to lie about this sensitivity that has the ability to affect their reputation,income and family life…well they are not trying to deceive…they are ‘re experiencing’ earlier long duration traumatic exposures…and in response to something like seeing a cell phone.

    Even if its turned off…such cases will manifest avoidance behaviors in presence of cell phones.
    Just like someone’s grandfather or friend that was ‘shell shocked’ in the last war!

  3. Pingback: Open Letter on the Electromagnetic Hyper-Sensitivity Research by Dariusz Leszczynski | Smart Meter News

  4. A few weeks ago, my tinnitus abated completely for a few hours. So did my wife’s. This has occurred before at this location, where there are relatively few offending emitters of e-pollution. I realized that there might be an area power outage – we have known for a long time that smart meters, the only constant polluters in this area of mostly seasonal and part-time residents, are particularly provocative of this symptom, which is now widespread as never before, as we find out in casual conversations regularly. This symptomatic abatement had occurred before during such an outage.

    So I phone the utility, and it was confirmed. It is obvious that our tinnitus abatement yet again was due to reduction of e-assault of this type. The tinnitus, along with the area electrical grid, was up and humming later that day. (We are off-grid with very small electrical usage mostly at zero, so had no ready daytime way to find out about any outage, no neighbours around either to ask.)

    This is a cinch – why are scientists stuck in so twisted a situation, that they cannot figure and arrange to verify something as simple as this? Of course, I have a lot to say about that. But I offer this comment here, in the urgent interest that nobody be taken by entanglements among researchers, so as to curb advocacy as if one need await wider and deeper research to make one’s point and recommendations about public and environmental health.

    A few comments, though, on such provocation studies as are written off by the professor here:

    In some studies, there have indeed been subjects who uncannily have been able to tell when an emitter of provocation was on or off. Yet for being very few with this “pinpoint” kind of accuracy, statistical rendering deflects attention therefrom. Instead, of course, research with such voluntary subjects should double down.

    Then there is fraught nomenclature, so that when an ailment pattern is described as an entity to deal with unto itself (such as, ‘chronic fatigue’, ‘fibromyalgia’, even ‘ALS’, the gamut really), not taking into account how electromagnetic function and dysfunction might crucially pertain, a crucial pattern concerning public and environmental health is missed. What is more general in physical terms accessible to some human understanding than electromagnetism? This point leans toward hearty endorsement of the professor’s call for research. But it should rather in advocacy lead to emphasizing that the naming of various syndromes, with attendant clustering of a community of narrowed research and caregiving, should not be allowed to obscure the general pattern. What research has been done to isolate from e-pollution – always to be suspected as causative or exacerbating – sufferers of all manner of ailments, to study response?

    This ties into a call for closer to “natural” versus laboratory environment for more patient and prolonged study of subjects, not after the fact epidemiologically, but maybe almost anthropologically. This kind of research I am confident would readily yield what is desperately needed for corrective in public and environmental health policy. Molecular research and the like could then serve to deepen understanding, so that amazing technologies can be re-engineered – or eliminated and replaced – from the bottom up, so as to do no or far less harm.

    Attempts at understanding must begin to reverse from sinking into the extreme specialization of today, which has allowed the field of generality, and thus public policy, to fall for evil or stupid purpose, as in overgeneralization of what might otherwise endure as highly specialized technology, but is now responsible for widespread creaturely destruction instead.

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