Hypothesis on mechanism for the ELF-EMF-induced biological effects

As the Chief Editor of the Frontiers in Radiation and Health (a specialty of the Frontiers in Public Health) it is my pleasure to announce that the FiR&H journal has just published its second article. The final version of the hypothesis article by Mats-Olof Mattsson and Myrtil Simko: “Grouping of experimental conditions as an approach to evaluate effects of extremely low-frequency magnetic fields on oxidative response in in vitro studies” is now freely available in open access system to all readers.

In the abstract of the article, the authors state:

“…A large body of literature deals with biological effects of extremely low-frequency magnetic fields (ELF MFs) studied in vitro. Despite the multitude of studies, no coherent picture has evolved regarding the plausibility of effects at low-flux densities or regarding the interaction mechanisms. Here, we propose that ELF MF exposure in vitro causes changes in oxidative status as an early response. We tested this hypothesis by scrutinizing the literature and applying a grouping approach for analyzing relevant biological properties and exposure conditions. A total of 41 scientific original publications were analyzed for this purpose. The conclusion from the work is that ELF MF (modulated or unmodulated) consistently can influence the oxidative status, at or above 1 mT, in a broad range of cell types and independent of exposure duration. A response at lower flux densities is seen in certain studies, although not consistently. Further studies with stringent protocols for sham exposure, blinding, and statistical analysis as well as appropriate positive controls are needed to establish if true dose-relationships for effects on oxidative status exist…”

The article was received in the editorial office on  01 August 2014; pending acceptance version was published on-line on 14 August 2014; Paper was formally accepted on 19 August 2014; the final version was published on-line on 02 September 2014.

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